Corrigendum: Biased Signaling of Protease-Activated Receptors
نویسندگان
چکیده
1 Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia 2 Department of Pharmacology, University of Melbourne, Melbourne, VIC, Australia *Correspondence: [email protected] Edited by: Michael Weiss, Case Western Reserve University, USA Reviewed by: Charles Roberts, Oregon National Primate Research Center, USA Michael Lawrence, The Walter and Eliza Hall Institute of Medical Research, Australia
منابع مشابه
Biased Signaling of Protease-Activated Receptors
In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain, and repair mechanisms. Certain proteases can signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled receptors. PARs are expressed b...
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The homeostatic blood protease, activated protein C (APC), can function as (1) an antithrombotic on the basis of inactivation of clotting factors Va and VIIIa; (2) a cytoprotective on the basis of endothelial barrier stabilization and anti-inflammatory and antiapoptotic actions; and (3) a regenerative on the basis of stimulation of neurogenesis, angiogenesis, and wound healing. Pharmacologic th...
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Most G protein-coupled receptors (GPCRs) are reversibly activated upon ligand binding. However, activation of protease-activated G protein-coupled receptors (PARs) occurs through an irreversible proteolytic event that results in the generation of a tethered ligand that cannot diffuse away. This unusual mode of PAR activation raises important questions regarding the mechanisms responsible for te...
متن کاملBiased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.
Activated protein C (APC) exerts endothelial cytoprotective actions that require protease-activated receptor 1 (PAR1), whereas thrombin acting via PAR1 causes endothelial disruptive, proinflammatory actions. APC's activities, but not thrombin's, require PAR1 located in caveolae. PAR1 is a biased 7-transmembrane receptor because G proteins mediate thrombin's signaling, whereas β-arrestin 2 media...
متن کاملTHROMBOSIS AND HEMOSTASIS Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
Activated protein C (APC) exerts endothelial cytoprotective actions that require protease-activated receptor 1 (PAR1), whereas thrombin acting via PAR1 causes endothelial disruptive, proinflammatory actions. APC’s activities, but not thrombin’s, require PAR1 located in caveolae. PAR1 is a biased 7-transmembrane receptor because G proteins mediate thrombin’s signaling, whereas -arrestin 2 mediat...
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